Grants are effective tools for creating sustainable innovation, collaboration, and education as well as community and stakeholder engagement. Because the culture of a not-for-profit organization and the practice of running it is always changing, innovation and employee engagement in the midst of these changes can be both challenging and expensive. Senior leadership can guide change by selecting grants fitting strategic priorities; thereafter, the grant mechanism, through project requirements, budget, deadlines, etc., provides the necessary structure for program development. Through appropriate grant development efforts, this process naturally brings about positive momentum for cultural change with the potential of generating a significant return on investment.